Symptoms of chronic overuse may present as hypercorticism and adrenal suppression, and patients may not require any more treatment than monitoring. Overdose with a mometasone furoate inhaler may occur with chronic overuse. Metaz also reduces inflammation by blocking transcription factors such as activator-protein-1 and nuclear factor kappa B (NF-kappaB). Once at the nucleus, receptors dimerize and bind to a DNA sequence known as the glucocorticoid response element which either increases expression of anti-inflammatory molecules or inhibits expression of pro-inflammatory molecules (such as interleukins 4 and 5). Metaz binding to a glucocorticoid receptor causes conformational changes in the receptor, separation from chaperones, and the receptor moves to the nucleus. ![]() Metaz has a particularly high receptor affinity compare to other corticosteroids, 22 times higher than that of dexamethasone. ![]() There is also evidence of inhibition of histamine, leukotrienes, and cytokines.Ĭorticosteroids diffuse across cell membranes into the cytosol of cells where they bind to glucocorticoid receptors to produce their activity. In asthma, mometasone is believed to inhibit mast cells, eosinophils, basophils, and lymphocytes. Metaz is also used to associated treatment for these conditions: Allergic Rhinitis (AR), Asthma, Dermatitis, Dermatitis, Eczematous caused by superficial Fungal skin infection, Moderate to Severe Plaque Psoriasis, Polyps, Nasal, Pruritus, Psoriasis, Psoriasis, Moderate to Severe, Seasonal Allergies, Skin Diseases, Eczematous, Skin Infections The ointment is indicated for symptomatic treatment of dermatitis and pruritis in patients ≥2 years. The nasal spray is indicated for treating nasal symptoms of allergic rhinitis in patients ≥2 years, treating symptoms of nasal congestion from seasonal allergic rhinitis in patients ≥2 years, treating nasal polyps in patients ≥18 years, and prophylaxis of seasonal allergic rhinitis in patients ≥12 years. The inhaler is indicated for prophylaxis of asthma in patients ≥4 years. There are 3 formulations of mometasone furoate with various indications. Hipersensibilidad a a cualquier otro corticosteroide.Metaz is a corticosteroid used to treat asthma, allergic rhinitis, nasal congestion, nasal polyps, dermatitis, and pruritus. Una terapia crónica con glucocorticoides puede interferir en el crecimiento y desarrollo del niño.No se ha establecido la seguridad de empleo en niños durante más de 6 sem. Aplicar la mínima cantidad de glucocorticoides necesaria para alcanzar eficacia. Los niños son más susceptibles a la supresión del axis pituitario hipotalámico y al síndrome de Cushing inducidos por glucocorticoides. Solución cutánea no hay experiencia en niños. Niños < 6 años falta de datos de seguridad (crema, emulsión y pomada). Riesgo de hiperglucemia y glucosuria, si hay absorción sistémica. ![]() Evitar la interrupción brusca del tto., puede desarrollarse un efecto de rebote que se manifiesta como una dermatitis con enrojecimiento intenso, quemazón y escozor. ![]() a largo plazo, en piel dañada o agtrietada, hay riesgo de toxicidad local y sistémica. No utilizar en la zona de los párpados y evitar contacto con los ojos no utilizar sobre piel dañada riesgo de irritación o sensibilización sobre superficies corporales grandes, vendaje oclusivo, tto.
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